HIV-2 (NIH-Z Strain) Purified Virus
Catalog #: 10-127-000
Size: 1.0 mg
In Stock
Biological Substance A
Human Immunodeficiency Virus type 2 (NIH-Z Strain) propagated in HuT 78 cells and purified from culture supernatant and cells showing cytopathic effect.
≥ 5 x 1010 viral particles per mL of purified HIV-2
> 106.0 TCID50 per mL of purified HIV-2
Typical lot size 100-500 vials
For research use only.
APPLICATION FOR USE
- In vitro Infectivity Assay
- Antiviral Studies
- Spiking Studies
- Virus Neutralization Assay
- Virus Ultrastructural Studies
- Nucleic Acid-Based Assay
QUALITY CONTROL TESTING INCLUDES
- Sterility
- TCID50
- Protein Concentration
- Virus Particle Count
SHIPPING AND STORAGE:
This product is shipped frozen on dry ice. Store at -70°C upon receipt. Avoid multiple freeze-thaw cycles as product degradation may result.
RECOMMENDATIONS:
Upon thawing, centrifuge the vial for a few seconds to remove residual droplets from the lid.
SAFE HANDLING RECOMMENDATIONS:
This preparation of HIV is a BIOHAZARDOUS material containing ACTIVE VIRUS and should be handled in accordance with biosafety guidelines defined in the BMBL, NIH-CDC HHS Publication No. (CDC) 21-1112.
REFERENCE ARTICLES
Jagodzinski, L., Manak, M., Hack, H., Liu, Y., and Peel, S. (2020). Performance evaluation of a laboratory developed PCR test for quantitation of HIV-2 viral RNA. PLOS ONE 15, e0229424. https://doi.org/10.1371/journal.pone.0229424
Palm, A., Lemey, P., Jansson, M., Månsson, F., Kvist, A., Szojka, Z., Biague, A., da Silva, Z., Rowland-Jones, S., and Norrgren, H. et al. (2019). Low Postseroconversion CD4+ T-cell Level Is Associated with Faster Disease Progression and Higher Viral Evolutionary Rate in HIV-2 Infection. mBio 10, e01245-18. https://doi.org/10.1128/mbio.01245-18
Trevino, A., Soriano, V., Poveda, E., Parra, P., Cabezas, T., Caballero, E., Roc, L., Rodriguez, C., Eiros, J., and Lopez, M. et al. (2014). HIV-2 viral tropism influences CD4+ T cell count regardless of viral load. Journal Of Antimicrobial Chemotherapy 69, 2191-2194. https://doi.org/10.1093/jac/dku119
Damond, F., Benard, A., Balotta, C., Boni, J., Cotten, M., Duque, V., Ferns, B., Garson, J., Gomes, P., and Goncalves, F. et al. (2011). An International Collaboration To Standardize HIV-2 Viral Load Assays: Results from the 2009 ACHIEV2E Quality Control Study. Journal Of Clinical Microbiology 49, 3491-3497. https://doi.org/10.1128/jcm.02389-10
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