HIV-1 (Ba-L Strain) Direct Pelleted Virus (500X)
Macrophage-tropic Human Immunodeficiency Virus type 1 (Ba-L Strain) concentrated 500 times from infected primary human monocyte/macrophage cell culture supernatant.
≥ 107.0 TCID50 per mL of HIV-1
Typical lot size 100-500 vials
For research use only.
APPLICATION FOR USE
- In vitro Infectivity Assay
- Antiviral Studies
- Nucleic Acid Extraction
- Spiking Studies
- Virus Neutralization Assay
QUALITY CONTROL TESTING INCLUDES
- Sterility
- Mycoplasma
- TCID50
- p24 Concentration
SHIPPING AND STORAGE:
This product is shipped frozen on dry ice. Store at -70°C upon receipt. Avoid multiple freeze-thaw cycles as product degradation may result.
RECOMMENDATIONS:
Upon thawing, centrifuge the vial for a few seconds to remove residual droplets from the lid.
SAFE HANDLING RECOMMENDATIONS:
This preparation of HIV is a BIOHAZARDOUS material containing ACTIVE VIRUS and should be handled in accordance with biosafety guidelines defined in the BMBL, NIH-CDC HHS Publication No. (CDC) 21-1112.
REFERENCE ARTICLES
Shieh, E., Marzinke, M., Fuchs, E., Hamlin, A., Bakshi, R., Aung, W., Breakey, J., Poteat, T., Brown, T., and Bumpus, N. et al. (2019). Transgender women on oral HIV pre-exposure prophylaxis have significantly lower tenofovir and emtricitabine concentrations when also taking oestrogen when compared to cisgender men. Journal Of The International AIDS Society 22, e25405. https://doi.org/10.1002/jia2.25405
Kononchik, J., Ireland, J., Zou, Z., Segura, J., Holzapfel, G., Chastain, A., Wang, R., Spencer, M., He, B., and Stutzman, N. et al. (2018). HIV-1 targets L-selectin for adhesion and induces its shedding for viral release. Nature Communications 9:2825. https://doi.org/10.1038/s41467-018-05197-2
Sowrirajan, B., Saito, Y., Poudyal, D., Chen, Q., Sui, H., DeRavin, S., Imamichi, H., Sato, T., Kuhns, D., and Noguchi, N. et al. (2017). Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox. Scientific Reports 7, 43441. https://doi.org/10.1038/srep43441
Tasker, C., Davidow, A., Roche, N., and Chang, T. (2017). Depot Medroxyprogesterone Acetate Administration Alters Immune Markers for HIV Preference and Increases Susceptibility of Peripheral CD4 + T Cells to HIV Infection. Immunohorizons 1, 223-235. https://doi.org/10.4049/immunohorizons.1700047
Dezzutti, C., Else, L., Yandura, S., Shetler, C., Russo, J., Back, D., and McGowan, I. (2016). Distinct Pharmacodynamic Activity of Rilpivirine in Ectocervical and Colonic Explant Tissue. Antimicrobial Agents And Chemotherapy 60, 2765-2770. https://doi.org/10.1128/aac.00167-16
Kumari, N., Ammosova, T., Diaz, S., Lin, X., Niu, X., Ivanov, A., Jerebtsova, M., Dhawan, S., Oneal, P., and Nekhai, S. (2016). Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease. Blood Advances 1, 170-183. https://doi.org/10.1182/bloodadvances.2016000745
Tasker, C., Subbian, S., Gao, P., Couret, J., Levine, C., Ghanny, S., Soteropoulos, P., Zhao, X., Landau, N., and Lu, W. et al. (2016). IFN-ε protects primary macrophages against HIV infection. JCI Insight 1, e88255. https://doi.org/10.1172/jci.insight.88255
Cardone, M., Ikeda, K., Varano, B., Gessani, S., and Conti, L. (2015). HIV-1-Induced Impairment of Dendritic Cell Cross Talk with γδ T Lymphocytes. Journal Of Virology 89, 4798-4808. https://doi.org/10.1128/jvi.03681-14
Ding, J., Tasker, C., Lespinasse, P., Dai, J., Fitzgerald-Bocarsly, P., Lu, W., Heller, D., and Chang, T. (2015). Integrin α4β7 Expression Increases HIV Susceptibility in Activated Cervical CD4+ T Cells by an HIV Attachment-Independent Mechanism. JAIDS Journal Of Acquired Immune Deficiency Syndromes 69, 509-518. https://doi.org/10.1097/qai.0000000000000676
Tasker, C., Ding, J., Schmolke, M., Rivera-Medina, A., García-Sastre, A., and Chang, T. (2014). 17β-Estradiol Protects Primary Macrophages Against HIV Infection Through Induction of Interferon-Alpha. Viral Immunology 27, 140-150. https://doi.org/10.1089/vim.2013.0120
- New Product
- Available as Custom Product-Discontinued
- Limited Quantities Remaining-Discontinued
- Call For Availability
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