TEM Services

Looking for a full service Electron Microscopy (EM) laboratory? We specialize in microbiology and virology applications on a cutting edge digital EM scope. For over 30 years our EM department has been serving the worldwide microbiology industry from start-up clients to the largest pharmaceutical companies. We will provide you with top quality images, fast turnaround time and a wealth of microbiology, virology and EM knowledge. Our facility also has the ability to accept many types of infectious biological samples.

Equipped with a Hitachi 7700 Transmission Electron Microscope, ABI colleagues are able to detect biological samples as small as 20nm. Our high quality images allow the examination of fine structure for the presence, absence, and quantification of known microbial or adventitiuos agents.

ABI’s services include, but are not limited to:

Imaging

ABI provides clients with digital photographs to aid in their quantitative or qualitative research efforts. These high resolution photographs are sent to the client in a digital format.

Turnaround time for this service is typically 1 week. Please contact us for a time estimate specific to your project.

Particle Counts

Preparations to be quantitated for viral burden are prepared by mixing a known concentration of latex spheres with the unknown number of virus particles in the sample. After enumerating the sample for both virus particles and latex spheres, ratios are used to determine the concentration of virus particles per milliliter. Samples to be processed for virus particle counts can be concentrated by ultracentrifugation if necessary.

Clients receive a Results Form for each sample, which will be sent in a digital format. Turnaround time for this service is typically 1 week. Please contact us for a time estimate specific to your project.

Intensive Search

Intensive searching of samples in TEM requires a slow and methodical visual screening of particles and biological specimens over large portions, if not entire surfaces, of prepared grids. These searches naturally yield a much higher amount of imaging per sample, which helps researchers access much more information than they would normally receive via particle counting. Digital photographs are provided along with a written report, including an interpretive summary of the search results obtained.

Turnaround time for this service is typically 2 weeks. Please contact us for a time estimate specific to your project.

Ultra-Thin Section Microscopy

Ultra-thin sectioning is the only method in electron microscopy where investigators can observe cells and tissues at an ultrastructural level with high resolution. This service allows investigators to directly observe the effects of disease or experimental manipulations on cell and tissue ultrastructure.

Specimens submitted for ultra-thin section analysis are fixed in electron microscopy grade fixatives, dehydrated, infiltrated, and embedded in plastic resin. The embedded cells or tissues are then ultra-thin sectioned using high quality diamond knives, which allows for direct electron microscopic observation of intracellular and extracellular areas of the cells or tissues.

Client receives all digital photographs along with an optional detailed report in digital format describing materials and methods used and providing an interpretive summary.

Turnaround time for this service is typically 2 weeks. Please contact us for a time estimate specific to your project.

If you don’t see the service that you are looking for, please contact us to get a custom quote for your project.

Our mission is to work backstage for your team to further beneficial work occurring in public health. We understand the value of your specimens and are excited to share our 30+ years of EM expertise to enrich each client project

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FAQs

Q: When does work on my TEM order start?

A: Work on your order begins once we receive the signed quote, purchase order, pre-payment (if required), samples and any other applicable materials.

Q: How do I send my samples/specimens?

A: Biohazardous specimens must be packaged and shipped according to current shipping regulations.

Validation data of inactivation must be provided along with inactivated specimens.

Q: Can ABI handle all types of specimens?

A: ABI does not handle or process the following specimens:

If you are uncertain as to whether or not your specimen falls into one of these categories, or have any questions, please Contact ABI to speak with a member of our technical support staff.

Q: How are reports received or images sent?

A: The reports and digital photographs are mailed on a flash drive.